Path breaking new study Discovers 5 new genes that cause Bowel Cancer
Ever since gene mapping technology was discovered, the process has thrown up amazing surprises and discoveries in helping locate genes responsible for disease. In a landmark study involving gene mapping, researchers have pinpointed five genes susceptible to mutation and subsequent disease, associated mainly with bowel cancer, one of the most common of diseases that shows up in 1.4 million people every year.
The new genes linked to bowel cancer will help experts in gaining more insight into the disease and locate improved medication for treatment of the same.
1 Largest Study for Bowel Cancer Ever
Although it has appeared in few cases. Researchers have finally mapped five new genes that can cause bowel cancer when mutated. Bowel cancer is a common occurrence where 1.5 million cases are found globally every year by a person’s gastroenterologist. The path breaking study involved genes for over a 1000 people all suffering from various stages of bowel cancer. The study is also the largest ever undertaken.
Funded by Cancer Research, UK and carried out at the Institute of Cancer Research, London, researchers have stated that the genes linked to bowel cancer have all been discovered. However, what the research found was that among the five mutated variants of the genes, they were responsible for just one-third of cancer cases under observation. The other factors responsible for bowel cancer included DNA variations, lifestyle, and factors of the environment.
2 New Discovery Will Lead To Minor Variants Causing Bowel Cancer
The study also found that 12 percent of cases were those who inherited such mutated genes like APC and MLH1, as they had a history of bowel cancer in the family. The main process of the study was gene studies of bowel cancer. This was enabled by completing an entire sequence of all DNA that produces protein. The data was taken from those with a hereditary risk of the disease and who acquired it when they were young. Moreover, the 1000 cases selected for the study were those who had the strongest susceptibility to the disease from among 250,000 cases.
With the discovery of five new genes, the number of genes causing bowel cancer has now gone up to 12 and the researchers are confident that there are no more. However, additional research is required for finding many more minor variants of genes, associated with bowel cancer. These are the genes linked to cases with an inherited risk and that is why these smaller DNA variants are equally important, where 30 have been discovered so far. With subsequent discoveries, the biology of bowel cancer will be easier to analyze, resulting in improved and accurate methods of treatment.
3 New Scope for Improved Methods of Treatment and Cure
According to lead researcher, Professor Richard Houston, the amazing new discovery of five genes linked to bowel cancer is the world’s largest genetic study conducted for the disease. The discovery of the five most important gene mutations responsible for the disease also opens up new avenues, that will ultimately lead to mapping of all the minor pieces in the puzzle of bowel cancer. He also mentioned that every single component discovered, provides valuable insight into the disease which will ultimately open up a scope for research for prevention and cure of the disease.