Scientists Discover Cancer Kill Switch Embedded In The Body That Can Brutally Eradicate Any Cancer Cell

6First discovered 20 years ago

These SiRNAs are now being researched as a means to suppress tumors. They were first discovered 20 years ago as siRNA’s and Micro RNAs or miRNA. As noncoding RNA, they played an important role in gene regulation. Medical technology has now enabled research on these molecules to be potential therapeutic agents for treatment in infections and cancer. The fact that they can be transfected means they can be made into drugs of which clinical trials are already underway.

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When was siRNA discovered

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7Humans have cancer-killing properties

Another research also discovered how the same sequences were found embedded in protein coding sequences throughout the human genome. According to Marcus Peter “We think this is how multicellular organisms eliminated cancer before the development of the adaptive immune system, which is about 500 million years old, it could be a fail-safe that forces rogue cells to commit suicide. We believe it is active in every cell protecting us from cancer.”

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Marcus Peter

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8How to find the process of siRNA production was the big question

What needed to be determined however is the process where the body is able to naturally produce free siRNAs to trigger the DISE procedure? This was an important factor because without siRNA production, the cancer killing sequence would not be initiated. Success was achieved in a new study that was published last month in eLife.

How to find the process of siRNA

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9Further study revealed the answers

In the new study, Peter and team discovered the process where human cells chop off a larger strand of RNA -which initiates the coding of CD95L, a protein that is involved in the cell death cycle-and creates multiple siRNAs.

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Rna study

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10A remarkable discovery

Further experiments revealed how the cellular mechanism could also be used to transform other larger protein-coding RNAs into cancer killing siRNAs to trigger DISE. What they found in these experiments was something remarkable. They found that no less than 3% of coding RNA within our genome could actually be processed for the purpose because of the wide network of the kill switch sequence in the genome.

A remarkable discovery

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