Children With Kawasaki Type Multi-inflammation Syndrome Test Negative for COVID-19 But Antibody Tests Shocks Researchers
7The children even required intensive care
All the 8 children had fever and one of them, abdominal and GI problems like stomach pain, diarrhea and vomiting. 6 of them required intensive care because of the infection affecting their heart, and low blood pressure caused by the disease. All children however, responded positively to treatment and were discharged from the ICU.
8Positive antibody tests confirmed the children had coronavirus much earlier
Research on the blood samples taken from the children using customized antibody tests at Southampton University revealed that they had already been infected by the coronavirus several weeks ago because their blood samples contained antibodies that bound and prevented the lab-made virus spike protein from latching on to their cells. Because of the delay in time, the PCR test was unsuccessful.
‘IgM was not detected in children, which contrasts with adult hospitalized adult COVID-19 patients of whom all had positive IgM responses,’ the researchers wrote in their study. It also explained ‘For antibody responses, IgM responses develop first, before eventually waning and IgG responses dominating thereafter, thus, high levels of IgG in the absence of IgM are typically suggestive of infection weeks or even months previously. ‘
9Only antibody tests can reveal new inflammation link to Coronavirus
After the study, researchers say that there is no other way of diagnosing patients infected with the severe inflammatory syndrome other than antibody testing. Researchers also said that ‘What the antibody test tells us is that these children have definitely been infected with SARS-CoV-2 at some time in the past, which will hopefully help doctors make decisions on how to treat these patients. ‘Ultimately, both PCR and antibody testing have overlapping roles to play in diagnosing this syndrome. Really excitingly, the detection of the antibodies may also provide clues on how this syndrome develops.’
10Researchers have concluded including WHO that the new inflammation is caused by COVID 19
The researchers also advocate changing the definition of PIMS-TS since the condition similar to Kawasaki is now confirmed as a SARS-CoV -2 infection and not a temporary symptom. In their new situation report dated 16th May 2020, World Health Body (WHO) has also acknowledged the new prevalence of a new inflammation in children calling it Multisystem Inflammatory Syndrome in Children and Adolescents with COVID-19: and has called for more research on the subject.